| Category Name | Content |
| Name | Restylane (Hyaluronic Acid Dermal Filler) |
| Uses | FDA-approved for facial wrinkles, folds, and volume restoration, including nasolabial folds, lips, and cheeks. Off-label uses include tear trough correction and jawline enhancement. |
| Route of Administration | Intradermal or subdermal injection. |
| Frequency of Use | Maximum every 3 months for elective patients. Effects last 6–18 months depending on the formulation used. |
| Concentration(s) | Varies by product: - Restylane-L: 20 mg/mL - Restylane Silk: 20 mg/mL - Restylane Lyft: 20 mg/mL - Restylane Refyne: 20 mg/mL - Restylane Defyne: 20 mg/mL |
| Maximum Dosage | Max 2.0 mL per session. Max 4.0 mL per 3-month period. |
| Contraindications | • Pregnancy, breastfeeding, or planning pregnancy. • Allergy to hyaluronic acid or lidocaine. • History of severe allergies, anaphylaxis, or autoimmune conditions. • Active skin infections, acne, or inflammation in the treatment area. • History of vascular occlusion, necrosis, or embolism from previous procedures. • Use of blood thinners or immunosuppressive medications. • Patients under 21 years old (per FDA approval). |
| Possible Side Effects | • Common: Swelling, bruising, tenderness, redness at injection sites. • Rare: Vascular occlusion, nodules, granulomas, hypersensitivity reactions. • Severe: Anaphylaxis, arterial embolization, tissue necrosis requiring surgical intervention. |
| Compatibility With Other Treatments/Drugs | • Safe with: Neuromodulators (Botox, Dysport), most dermal fillers. • Avoid with: Recent laser treatments, chemical peels, or other dermal fillers within the last 3 months. |
| Allergies | Patients allergic to hyaluronic acid or lidocaine should not receive treatment. |
| Administration Time | Injection procedure takes approximately 30–45 minutes, including preparation and aftercare. |
| Dosing/Settings | • Recommended starting dose: 0.5 mL per area, gradually increasing as needed. • Maximum 1.0 mL per side (cheeks, jawline) in a single session. • Use small bolus injections or linear threading technique for best results. |
| What To Do If Adverse Reaction Occurs | • Vascular occlusion: Stop injection immediately, apply warm compress, massage area, administer hyaluronidase if needed. • Anaphylaxis: Administer epinephrine (0.3 mg IM), call 911, provide airway support. • Granulomas: Refer to dermatology for corticosteroid or 5-FU treatment. • Necrosis: Immediate referral to a specialist for wound care and potential debridement. |
| Additional Documentation Requirements | • Signed informed consent form. • Pre-treatment photos (frontal and side views). • Medical clearance if history of vascular complications, autoimmune disease, or recent oncology treatment. • Documentation of past filler treatments and allergy history. |
| Post-Treatment Care Instructions | • Avoid strenuous exercise, alcohol, and excessive sun exposure for 24 hours. • Apply cold compress if swelling or bruising occurs. • Do not manipulate or massage the treated area unless instructed by the provider. • Follow up in 2–4 weeks for reassessment and potential touch-up treatment if needed. |