| Category Name | Content |
| Name | Platelet-Rich Plasma (PRP) & Platelet-Rich Fibrin (PRF) Therapy |
| Uses | Autologous platelet concentrate treatments used for skin rejuvenation, hair restoration, wound healing, and joint/muscle recovery. PRP is rich in growth factors, while PRF has a higher concentration of fibrin and leukocytes for sustained release of growth factors. |
| Route Of Administration | Injected subdermally, intradermally, or applied topically (microneedling, post-laser). |
| Frequency Of Use | Typically performed every 4-6 weeks for an initial series of 3-4 treatments; maintenance treatments every 6-12 months as needed. |
| Concentration(s) | Preparation varies based on centrifuge settings and technique: - **PRP:** 2-5x baseline platelet concentration - **PRF:** Fibrin matrix with slower growth factor release |
| Maximum Dosage (Day, Wk) | One treatment per session, with 10-15 mL of blood drawn per area treated. Avoid excessive injections per session to minimize bruising and inflammation. |
| Contraindications | Pregnancy, breastfeeding, active skin infections, history of keloids, autoimmune disorders, active cancer, platelet dysfunction syndromes, or use of anticoagulants (unless discontinued safely). |
| Possible Side Effects | Mild swelling, bruising, tenderness, redness, temporary discomfort, rare risk of infection, or excessive inflammation. |
| Compatibility With Other Treatments/Drugs | Safe to combine with microneedling, RF microneedling, laser therapy, and exosome therapy. Avoid aggressive treatments (deep chemical peels, ablative lasers) within 4 weeks of PRP/PRF application. |
| Allergies | Assess for hypersensitivity to topical numbing agents or post-procedure serums, though PRP/PRF itself is autologous and unlikely to cause allergic reactions. |
| Administration Time | 45-60 minutes per session, including blood draw, centrifugation, and application. |
| Dosing/Settings | Standard treatment protocol: - **PRP/PRF Injection:** 1-2 mL per facial area, scalp, or joint - **Microneedling (Topical PRP/PRF):** 3-5 mL applied post-treatment |
| Test Spot Requirement | Not required, but recommended for first-time patients to assess response and healing. |
| Pre-Treatment Guidelines | - Hydrate well 24-48 hours before treatment to improve blood draw quality. - Avoid NSAIDs, anticoagulants, and alcohol for 5-7 days before treatment. - Ensure skin is clean and free of makeup, lotions, or sunscreen before the procedure. |
| Provider Clearance Guidelines | - Ensure the patient meets all clearance criteria before treatment. - If the patient has a history of clotting disorders or autoimmune conditions, proceed with caution and obtain specialist clearance if needed. - Document all clearance decisions in the patient’s medical record. |
| Pre-Treatment Screening Workflow | - Is the patient on blood thinners? (If YES, consult before proceeding) - Does the patient have a history of keloid formation? (If YES, proceed with caution and document risk counseling) - Is the patient currently pregnant or breastfeeding? (If YES, contraindicated) |
| What To Do If Adverse Reaction Occurs | - **Excessive swelling or bruising**: Apply cold compress and recommend arnica gel. - **Infection (rare)**: If suspected, swab for culture and start empirical antibiotic therapy. - **Delayed healing or persistent redness**: Consider post-treatment LED therapy or hydrating serums to aid recovery. |
| Clinic Implementation Guidelines | - Confirm all consents are signed before treatment. - Use proper aseptic technique for blood draw and centrifugation. - Store PRP/PRF in sterile conditions and apply within the recommended time window. - Conduct post-treatment follow-up within 2-4 weeks. |
| Photographic Documentation Protocol | - Take pre-treatment photos from standardized angles (front, side, close-up views). - Take post-treatment photos at follow-up visits to track progress. - Store images securely in the patient’s medical record. |
| Post-Treatment Care | - Avoid direct sun exposure for at least 72 hours post-treatment; apply SPF 50+ daily. - Avoid makeup, retinoids, or exfoliating products for 24-48 hours post-treatment. - Mild swelling and bruising may persist for up to 48 hours. - Follow-up treatments should be scheduled based on provider recommendations. |
| Additional Documentation Requirements | - Signed informed consent detailing risks, benefits, and post-care instructions. - Treatment log including PRP/PRF preparation details, injection sites, and patient response. - Post-treatment care instructions provided and documented. |