| Category Name | Content |
| Name | Exosome Therapy |
| Uses | Regenerative treatment used for skin rejuvenation, hair restoration, wound healing, and anti-aging benefits. Supports cellular repair, reduces inflammation, and promotes collagen synthesis. |
| Route Of Administration | Injected intradermally, applied topically post-microneedling, or infused via IV (where applicable per clinical guidelines). |
| Frequency Of Use | Typically once every 3-6 weeks for 3-5 sessions, depending on the indication. Maintenance treatments may be performed every 3-6 months. |
| Concentration(s) | Varies by manufacturer; provider must verify proper dilution and handling before administration. Common dosing ranges: - **Topical (Microneedling/Facial Rejuvenation)**: 2-5mL per session - **Injection (Hair Restoration/Skin Rejuvenation)**: 0.1-0.2mL per injection site - **IV Infusion (Regenerative Therapy)**: 5-15mL in 100-250mL saline (off-label, requires specialized provider oversight). |
| Maximum Dosage (Day, Wk) | Follow manufacturer-recommended guidelines. Maximum treatment areas should not exceed provider safety limits per session. |
| Contraindications | Pregnancy or breastfeeding, active skin infections, autoimmune disorders affecting skin healing, uncontrolled diabetes, history of keloid scarring (for injections), active cancer, or recent immunosuppressive therapy. |
| Possible Side Effects | Mild redness, swelling, tenderness at injection sites, transient headache (IV administration), rare allergic reactions, or localized bruising. |
| Compatibility With Other Treatments/Drugs | Safe to combine with PRP, microneedling, laser treatments, and RF therapy. Avoid concurrent use with immunosuppressants, steroids, or chemotherapy agents. |
| Allergies | Screen for allergies to preservatives or carrier solutions used in exosome formulations. |
| Administration Time | 15-60 minutes per session, depending on method of delivery (injection, topical, or IV infusion). |
| Dosing/Settings | Customized per patient needs: - **Topical (Microneedling/Post-Laser Application)**: 2-5mL applied over the treatment area - **Injection (Hair/Face Rejuvenation)**: 0.1-0.2mL per injection site using a 30G needle - **IV Infusion (Regenerative Therapy)**: 5-15mL diluted in 100-250mL of saline over 30-60 minutes (off-label, requires specialized protocol) |
| Test Spot Requirement | Recommended for first-time patients receiving exosome injections. Apply a small amount and observe for 24-48 hours for hypersensitivity. |
| Pre-Treatment Guidelines | - Stop anti-inflammatory medications 48 hours prior to treatment. - Avoid retinoids, exfoliating agents, or harsh skincare 5-7 days before treatment. - Ensure skin is clean and free of makeup or lotions before application. - For hair restoration: Wash hair before the procedure; avoid topical hair products the day of treatment. - For IV administration: Hydrate well before infusion, and ensure proper venous access. |
| Provider Clearance Guidelines | - Ensure patient meets all clearance criteria before proceeding. - If the patient has a history of autoimmune conditions, consult a physician before administration. - Document all clearance decisions in the patient’s medical record. |
| Pre-Treatment Screening Workflow | - Does the patient have a history of autoimmune disease? (If YES, proceed with caution and consult physician if needed) - Has the patient received recent immunosuppressive therapy? (If YES, contraindicated) - Is the patient pregnant or breastfeeding? (If YES, contraindicated) - Does the patient have a history of severe allergic reactions? (If YES, perform a patch test before treatment) |
| What To Do If Adverse Reaction Occurs | - **Redness, swelling, or irritation**: Apply a cold compress and monitor. - **Severe pain or prolonged swelling at injection sites**: Consider a short course of antihistamines or mild steroids if necessary. - **Anaphylaxis (rare)**: Stop treatment immediately, administer epinephrine 0.3mg IM, and call 911. - **IV-related reactions (headache, dizziness, flushing)**: Stop infusion, monitor vitals, and hydrate patient. |
| Clinic Implementation Guidelines | - Ensure exosomes are stored properly per manufacturer instructions (typically frozen, thawed before use). - Use sterile technique for injections and microneedling applications. - For IV administration, ensure proper dilution and slow infusion rate. - Document batch number, patient response, and any adverse events in the medical record. |
| Photographic Documentation Protocol | - Capture pre-treatment photos for skin and hair applications. - Take post-treatment photos at follow-ups to assess improvement. - Store securely in the patient’s medical record. |
| Post-Treatment Care | - Avoid makeup, harsh skincare, or sun exposure for 48 hours post-treatment. - Encourage hydration and use of gentle, non-irritating skincare. - For IV therapy, advise patients to rest and hydrate post-infusion. - Follow-up treatments should be scheduled based on provider recommendations. |
| Additional Documentation Requirements | - Signed informed consent detailing treatment expectations and risks. - Patient history screening for contraindications. - Treatment session log including dosage, method of application, and patient response. - Post-treatment recommendations provided and documented. |