| Name | Amlexanox (Compounded & Branded Formulations). |
| Uses | Treatment of recurrent aphthous ulcers (canker sores), potential metabolic and anti-inflammatory applications, obesity-related inflammation, and insulin resistance. |
| Route Of Administration | Topical (oral paste), Oral (capsules, tablets). |
| Frequency Of Use | Topical: Apply 2-4 times daily. Oral: Once or twice daily as prescribed. |
| Concentration(s) | Topical: 5% paste. Oral: 50mg, 100mg capsules or tablets. |
| Maximum Dosage (Day, Wk) | Topical: Max 4 applications/day. Oral: Max 100mg twice daily. |
| Contraindications | Hypersensitivity to amlexanox, pregnancy, lactation, active gastrointestinal ulcers, severe renal or hepatic impairment. |
| Possible Side Effects | Oral irritation (topical use), nausea, diarrhea, dizziness, headache, potential liver enzyme elevation with oral use. |
| Compatibility With Other Treatments/Drugs | Use caution with immunosuppressants, anti-inflammatory medications, and anticoagulants. |
| Allergies | Check for hypersensitivity to amlexanox or excipients in compounded formulations. |
| Administration Time | Topical: Apply after meals and at bedtime. Oral: Morning or as directed by provider. |
| Dosing/Settings | Topical: Small amount applied directly to ulcer. Oral: 50-100mg once or twice daily. |
| Test Spot Requirement | Not required unless history of hypersensitivity. |
| Pre-Treatment Guidelines | Assess oral or metabolic condition, baseline liver function test (LFTs) if oral therapy is considered. |
| Provider Clearance Guidelines | Ensure no contraindications, verify clinical indication, discuss potential benefits and risks with patient. |
| Pre-Treatment Screening Workflow | 1. Verify indication. 2. Assess contraindications. 3. Obtain informed consent. 4. Review baseline labs if applicable. |
| What To Do If Adverse Reaction Occurs | For mild symptoms (irritation, nausea): Monitor and adjust dose. For severe reactions (allergic response, liver enzyme elevation): Discontinue and consult specialist. |
| Clinic Implementation Guidelines | Confirm prescription, educate patient on proper use, document treatment details in EMR. |
| Photographic Documentation Protocol | Not required unless significant irritation or reaction occurs. |
| Post-Treatment Care | Monitor symptoms, reassess treatment efficacy in follow-up visits, adjust dosage as needed. |
| Additional Documentation Requirements | Signed informed consent, treatment logs, prescription details, and adverse event documentation if applicable. |
| Special Notes | Amlexanox is primarily used for ulcer treatment, but its metabolic effects are under research; use should be carefully monitored. |