| Name | Sodium Phosphate |
| Uses | Phosphate source used to support electrolyte balance, cellular energy production (ATP synthesis), and bone health. In wellness settings, sodium phosphate may be used for electrolyte replenishment in active individuals or to correct mild phosphate deficiency. |
| Route Of Administration | Intravenous (IV) |
| Frequency Of Use | Typically administered once every 2 to 4 weeks if clinically indicated by lab results or symptoms (e.g., fatigue, muscle weakness). Frequency should be reassessed after 4 to 6 treatments. |
| Concentration(s) | Common concentration: 3 mmol/mL phosphate with 4 mEq sodium/mL. |
| Maximum Dosage (Day, Wk) (g/mL)/mL | Maximum dose per infusion: 15 mmol phosphate IV. Maximum weekly dose: 30 mmol. Excessive phosphate administration increases risk of electrolyte imbalances (hyperphosphatemia, hypocalcemia). |
| Contraindications | Hyperphosphatemia, severe renal impairment, severe hypocalcemia, or hypernatremia. Known hypersensitivity to sodium phosphate or formulation components. Use with caution in patients with cardiac disease, hypertension, or fluid overload. |
| Possible Side Effects | Flushing, nausea, mild dizziness, or thirst during infusion. Injection site irritation. Rare: allergic reaction (rash, itching, hypersensitivity). High doses may cause hypocalcemia, muscle cramps, or tetany. |
| Compatibility With Other Drugs | Compatible with normal saline and D5W. Should not be mixed directly with calcium-containing solutions (risk of precipitation). Compatibility should always be verified before combining with vitamins, amino acids, or minerals. |
| Allergies | True allergy to sodium phosphate is rare, but hypersensitivity to preservatives or stabilizers in compounded formulations may occur. |
| Administration Time | Typical infusion time: 30 to 60 minutes when part of a multi-nutrient IV blend. |
| IV Dosing | For general wellness and phosphate replenishment: 5 mmol to 15 mmol IV every 2 to 4 weeks, adjusted based on clinical need and lab values. |
| IM/Push | Not recommended for IM use. IV push is also not recommended due to vein irritation and risk of rapid electrolyte shifts. Slow IV infusion is preferred. |
| What To Do If Adverse Reaction Occurs | 1. Stop the infusion immediately if a reaction occurs. 2. Assess vital signs (blood pressure, heart rate, oxygen saturation). 3. If flushing, nausea, or dizziness occurs, slow the infusion rate and provide supportive care. 4. For allergic reactions (rash, itching, shortness of breath), administer antihistamines and consider epinephrine if severe. 5. If electrolyte disturbance is suspected (muscle cramps, tetany, confusion), obtain immediate electrolyte panel. 6. If symptoms persist or worsen, arrange for emergency transfer to a higher level of care (call 911 if necessary). |