Vitamin K

Name	Vitamin K
Uses	Fat-soluble vitamin essential for blood clotting, bone metabolism, and cardiovascular health. In wellness settings, Vitamin K may be included in IV formulations to support bone strength, cardiovascular health, and address mild deficiencies in patients with poor dietary intake.
Route Of Administration	Intravenous (IV)
Frequency Of Use	Typically administered once every 2 to 4 weeks for general wellness, depending on clinical assessment. Frequency should be reassessed after 8 to 12 weeks.
Concentration(s)	Common concentration: 1 mg/mL (phytonadione - Vitamin K1).
Maximum Dosage (Day, Wk) (g/mL)/mL	Maximum dose per infusion: 5 mg. Maximum weekly dose: 5 mg. Higher doses are generally unnecessary in wellness patients and increase risk of clotting abnormalities.
Contraindications	Known hypersensitivity to Vitamin K or formulation components. Active thromboembolic disease. Severe liver disease with coagulopathy. Pregnancy and breastfeeding unless cleared by OB provider. Use caution in patients taking anticoagulants, as Vitamin K may antagonize their effects.
Possible Side Effects	Flushing, taste changes, dizziness, or nausea during infusion. Injection site irritation. Rare: allergic reaction (rash, itching, hypersensitivity). Excessive or unmonitored dosing may affect clotting balance.
Compatibility With Other Drugs	Compatible with normal saline and D5W. Typically administered alone due to its fat-soluble nature, but may be combined with other fat-soluble vitamins if compatibility confirmed.
Allergies	True allergy to Vitamin K is rare, but hypersensitivity to preservatives or stabilizers in compounded formulations may occur.
Administration Time	Typical administration time: 15 to 30 minutes when diluted appropriately in carrier fluid (e.g., normal saline).
IV Dosing	For general wellness and bone support: 1 mg to 5 mg IV every 2 to 4 weeks, adjusted based on clinical assessment and dietary intake.
IM/Push	May be given IM at similar doses (1 mg to 5 mg) if preferred for slower release. IV infusion is generally better tolerated in elective wellness patients.
What To Do If Adverse Reaction Occurs	1. Stop the infusion immediately if a reaction occurs. 2. Assess vital signs (blood pressure, heart rate, oxygen saturation). 3. If flushing, dizziness, or nausea occurs, slow the infusion rate and provide supportive care. 4. For allergic reactions (rash, itching, shortness of breath), administer antihistamines and consider epinephrine if severe. 5. If clotting abnormalities are suspected (swelling, pain, or redness in extremities), arrange for urgent evaluation and imaging if indicated. 6. If symptoms persist or worsen, arrange for emergency transfer to a higher level of care (call 911 if necessary).