| Name | Vitamin D |
| Uses | Fat-soluble vitamin essential for calcium absorption, bone health, immune function, and inflammatory regulation. In wellness settings, Vitamin D may be included in IV formulations to support immune health, bone strength, and general wellness—especially in patients with low sun exposure or mild deficiency. |
| Route Of Administration | Intravenous (IV) |
| Frequency Of Use | Typically administered once every 2 to 4 weeks for general wellness and immune support. Frequency should be reassessed after 8 to 12 weeks based on clinical assessment and serum Vitamin D levels. |
| Concentration(s) | Common concentration: 100,000 IU/5 mL (20,000 IU/mL) (usually Vitamin D3 - cholecalciferol). |
| Maximum Dosage (Day, Wk) (g/mL)/mL | Maximum dose per infusion: 100,000 IU (5 mL). Maximum weekly dose: 100,000 IU. High doses should only be given when Vitamin D deficiency is confirmed by lab work. |
| Contraindications | Hypercalcemia. Known hypersensitivity to Vitamin D or formulation components. Severe renal impairment. Active granulomatous diseases (e.g., sarcoidosis) where calcium metabolism may be abnormal. Pregnancy and breastfeeding unless specifically cleared by OB provider. |
| Possible Side Effects | Nausea, headache, or fatigue following infusion. Injection site irritation. Rare: allergic reaction (rash, itching, hypersensitivity). Excessive dosing over time can lead to hypercalcemia with symptoms such as confusion, weakness, constipation, and cardiac arrhythmias. |
| Compatibility With Other Drugs | Typically infused alone due to its fat-soluble nature. Should not be combined with calcium-containing solutions in the same line unless compatibility is confirmed. Usually not combined in standard wellness IV blends. |
| Allergies | True allergy to Vitamin D itself is rare, but sensitivity to preservatives, stabilizers, or carriers in compounded formulations is possible. |
| Administration Time | Typical administration time: 5 to 15 minutes when diluted appropriately in carrier fluid (e.g., normal saline). |
| IV Dosing | For general wellness and immune support: 50,000 IU to 100,000 IU IV every 2 to 4 weeks, adjusted based on serum levels and clinical assessment. |
| IM/Push | May be given IM at similar doses (50,000 IU to 100,000 IU) for slower release over time. IV infusion preferred for faster effect. |
| What To Do If Adverse Reaction Occurs | 1. Stop the infusion immediately if a reaction occurs. 2. Assess vital signs (blood pressure, heart rate, oxygen saturation). 3. If nausea, headache, or fatigue occurs, provide supportive care and monitor closely. 4. For allergic reactions (rash, itching, shortness of breath), administer antihistamines and consider epinephrine if severe. 5. If hypercalcemia symptoms are suspected (confusion, weakness, arrhythmias), check serum calcium and initiate hydration and supportive management. 6. If symptoms persist or worsen, arrange for emergency transfer to a higher level of care (call 911 if necessary). |