Selenium

Name	Selenium
Uses	Trace mineral used to support antioxidant defense, immune function, and thyroid health. In wellness settings, selenium may be included in IV formulations for immune support, detoxification enhancement, and to correct mild dietary deficiencies.
Route Of Administration	Intravenous (IV)
Frequency Of Use	Typically administered once every 2 to 4 weeks if indicated by clinical assessment or lab testing. Frequency should be reassessed after 8 to 12 weeks of use.
Concentration(s)	Common concentration: 40 mcg/mL (sodium selenite or sodium selenate). Final concentration depends on the compounded formulation.
Maximum Dosage (Day, Wk) (g/mL)/mL	Maximum dose per infusion: 200 mcg. Maximum weekly dose: 200 mcg. Higher doses are not recommended for elective wellness patients due to risk of selenium toxicity (selenosis).
Contraindications	Known hypersensitivity to selenium salts. Severe renal impairment (due to impaired clearance). Active thyroid disease unless cleared by endocrinologist. Pregnancy and breastfeeding unless cleared by OB provider.
Possible Side Effects	Nausea, metallic taste, or garlic-like breath odor. Flushing or dizziness during infusion. Injection site irritation. Rare: allergic reaction (rash, itching, hypersensitivity). Prolonged excessive intake may lead to selenium toxicity (hair loss, brittle nails, neurological symptoms).
Compatibility With Other Drugs	Compatible with normal saline and D5W. Can generally be combined with vitamins, amino acids, and minerals in comprehensive wellness IVs, but compatibility should always be verified before mixing.
Allergies	True allergy to selenium is rare, but reactions to preservatives or stabilizers in compounded formulations are possible.
Administration Time	Typical infusion time: 30 to 60 minutes when part of a multi-nutrient IV blend.
IV Dosing	For general antioxidant and immune support: 100 mcg to 200 mcg IV every 2 to 4 weeks, adjusted based on clinical need and dietary intake.
IM/Push	IM administration is not recommended due to irritation risk. Slow IV infusion is preferred for tolerability and safety.
What To Do If Adverse Reaction Occurs	1. Stop the infusion immediately if a reaction occurs. 2. Assess vital signs (blood pressure, heart rate, oxygen saturation). 3. If flushing, dizziness, or metallic taste occurs, slow the infusion rate and provide supportive care. 4. For allergic reactions (rash, itching, shortness of breath), administer antihistamines and consider epinephrine if severe. 5. If symptoms persist or worsen, arrange for emergency transfer to a higher level of care (call 911 if necessary).