| Name | Magnesium Chloride |
| Uses | Essential mineral used to support muscle function, nerve conduction, cardiovascular health, and electrolyte balance. In wellness settings, it may be included in IV formulations for muscle recovery, relaxation, migraine prevention, and general electrolyte support. |
| Route Of Administration | Intravenous (IV) |
| Frequency Of Use | Typically administered once weekly for general wellness support. May be given up to twice weekly for muscle recovery or migraine prevention, followed by reassessment after 4 to 6 weeks. |
| Concentration(s) | Common concentration: 200 mg/mL. |
| Maximum Dosage (Day, Wk) (g/mL)/mL | Maximum dose per infusion: 1 g (5 mL of 200 mg/mL solution). Maximum weekly dose: 2 g. Excessive dosing increases risk of hypotension and magnesium toxicity. |
| Contraindications | Severe renal impairment (risk of hypermagnesemia). Heart block (without a pacemaker). Myasthenia gravis. Known hypersensitivity to magnesium chloride or any formulation component. Pregnancy and breastfeeding unless cleared by OB provider. |
| Possible Side Effects | Flushing, warmth, or dizziness during infusion. Mild nausea. Injection site irritation. Rare: hypotension, respiratory depression, or allergic reaction (rash, itching, anaphylaxis). |
| Compatibility With Other Drugs | Compatible with normal saline and D5W. May precipitate when mixed directly with calcium-containing solutions. Compatibility must always be verified when adding to multi-ingredient IVs. |
| Allergies | True allergy to magnesium chloride is rare. Reactions are more likely related to preservatives in compounded formulations. |
| Administration Time | Typical infusion time: 30 to 60 minutes. Slower infusion improves tolerability and reduces risk of flushing or hypotension. |
| IV Dosing | For general wellness and muscle recovery: 500 mg to 1 g IV once weekly. For migraine prevention: 1 g IV once weekly for 4 to 6 weeks, followed by reassessment. |
| IM/Push | Slow IV push may be used for doses up to 500 mg, given over 5 to 10 minutes. IM administration is not recommended due to pain and variable absorption. |
| What To Do If Adverse Reaction Occurs | 1. Stop the infusion immediately if a reaction occurs. 2. Assess vital signs (blood pressure, heart rate, oxygen saturation). 3. If flushing, dizziness, or warmth occurs, slow the infusion rate and provide supportive care. 4. For allergic reactions (rash, itching, shortness of breath), administer antihistamines and consider epinephrine if severe. 5. If hypotension develops, provide a fluid bolus (normal saline) and monitor closely. 6. If symptoms persist or worsen, arrange for emergency transfer to a higher level of care (call 911 if necessary). |